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A chemical cocktail for age reversal to revolutionise the treatment of ageing

August 18th, 2023

The latest discovery is an age-reversal breakthrough that could enable whole-body rejuvenation, using a chemical approach to revolutionise the treatment of ageing, age-related diseases and injuries.

It’s an epic anti-ageing discovery

 On July 12th 2023, researchers at the Harvard Medical School at the University of Maine and MIT published a new research paper in Aging called, ‘Chemically induced reprogramming to reverse cellular ageing’. The medical paper revealed groundbreaking monumental discoveries opening up new avenues for regenerative medicine and whole-body rejuvenation.

Nobel Prize winners

 The study is an extension of the scientist’s Nobel Prize-winning research to find if it is possible to reverse cellular ageing without causing cells to become too young and turn cancerous. The scientific experts demonstrated that it was possible to slow cellular ageing without uncontrolled cell growth by powerful gene therapy, virally introducing Yamanaka factors which converted adult cells into induced Pluripotent stem cells (iPSCs).

They have gone one step further…

The development of a chemical cocktail, the alternative to powerful gene therapy

 The lead scientist of the new research David A. Sinclair, A.O., PhD, Professor in the Department of Genetics and Co-Director of the Paul F. Glenn Center for Biology of Ageing Research at Harvard Medical School and his team was responsible for finding a chemical method to reverse ageing.

The Professor explained, “Until recently, the best we could do was slow ageing. New discoveries suggest we can now reverse it. This process has previously required gene therapy, limiting its widespread use.

Molecule mixing creates a potent anti-ageing cocktail

 In the latest research, the experts screened for molecules that, in combination, could reverse ageing and rejuvenate human cells. What they found is a potent chemical cocktail.

Using vital experimental tools, the team wanted to find a process that didn’t alter the genome in the body. The genome is the genetics of an organism.

The process they went through could distinguish young from old and senescent cells.

The team identified six chemical cocktails that restore nucleocytoplasmic protein compartmentalization (NCC) and genome-wide transcript profiles to a youthful state and reverse transcriptomic age in less than a week.

The study focused on cells in the brain, optic nerve, kidneys and muscles in mice which were engineered to age rapidly to test the effectiveness of the chemical cocktails.

Improved vision and extended life span

 The test results were promising. There was improved vision and extended life span in the mice.

Recently, the same tests and research included vision in monkeys which gave positive results in reversing blindness.

This is the first chemical approach to reprogramming cells to a younger state. Preparations are now in place for human trials, who knows what tomorrow will bring.

Read the full study here.

The research team at the Harvard Medical School at the University of Maine and MIT included Jae-Hyun Yang, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen, Patrick T. Griffin, Matthew Arnold, Jien Li, Oswaldo A. Martinez, Alexander Behn, Ryan Rogers-Hammond, Suzanne Angeli, Vadim N. Gladyshev, and David A. Sinclair.



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