Declaration: IAS Aging Matters Magazine is intended for IAS private members (and therefore is not intended for the public). It focuses on the latest international nutritional, hormonal and drug therapies to help combat the signs of aging. If you continue to use this site we will assume that you have read and agreed to the full declaration.

Read the full declaration
Close up of blue and green nerve cells

5-HTP, the natural SSRI alternative

November 26th, 2016

5-HTP, the natural SSRI alternative

By James South, MA


5-HTP (otherwise known as 5-hydroxy-tryptophan or oxitriptan), is the less well known cousin of serotonin (5-HT), one of the most important brain neurotransmitters.


5HTP vs. tryptophan

The amino acid L-tryptophan found within our diet is first converted to 5-HTP inside the body by nerve cells via a vitamin B3 dependant enzyme and then 5-HTP is converted to 5-HT by a vitamin B6 dependant enzyme. Yet now, thanks to modern science, we can take preformed 5-HTP, with its many consequent advantages.

5-HTP passes through the blood brain barrier into the brain far more easily than tryptophan and getting tryptophan through the blood brain barrier is the main bottleneck, which in many people leads to inadequate brain serotonin levels. Also, 5-HTP is not used to make proteins in the body, while tryptophan is, so there isn’t competition by cells outside the brain for 5-HTP, as there is for the body’s scare tryptophan supplies.

The body often uses tryptophan to make vitamin B3, at a very high cost of 60 mg L-tryptophan to make just 1 mg of B3! However, 5-HTP is not wasted in this way to make vitamin B3.

L-tryptophan can be broken down in the liver by pyrrolase, an enzyme that converts tryptophan to kynurenine and its metabolites, which can be mildly liver toxic at high levels. But, 5-HTP is not metabolized through this pathway.

Because of this, L-tryptophan supplementation especially in chronically stressed people should be kept to 1 gram (1000 mg) per day or less, because the stress hormone- cortisol activates pyrrolase.


Serotonin and mood

The work of HM van Praag, SN Young and others over the last 20 years, shows that serotonin is a key brain neurotransmitter involved in mood regulation (anti-anxiety and anti-depression), impulse control, (it inhibits aggression and obsessive compulsive disorders [OCD] and pain). Serotonin is also the precursor for our pineal gland’s production of melatonin.

Human clinical studies show that 5-HTP is a far more efficient increaser of brain serotonin than L-tryptophan. Furthermore, when 5-HTP has been compared to tryptophan in human studies, 5-HTP has been a far more successful antidepressant, even when the tryptophan dosage used is 10 to 15 times higher than the 5-HTP dosage. Also, relapses back into depression are more common with tryptophan than with 5-HTP.

Unlike tryptophan, 5-HTP has also been shown to increase brain dopamine and noradrenaline activity. These are two key mood and alertness regulating neurotransmitters and when tyrosine, the amino-acid precursor for brain dopamine/ noradrenaline is given along with 5-HTP, the effect is even more powerful.


5HTP vs. SSRI’s

In a society that has made the serotonin-selective re-uptake inhibitor (SSRI) drugs such as Prozac® the gold standard of managing the serotonin-deficiency syndrome, (note: even though the Poeldinger study showed 5-HTP to be superior to it), it is worth noting that a study reported by Risch and Nemeroff demonstrates, that even those successfully treated with SSRIs (ignoring their frequent and sometimes serious side effects), are still dependent upon their brains’ producing adequate serotonin from either tryptophan or 5-HTP.


SSRIs vs 5-HTP

SSRIs work by conserving existing brain serotonin supplies by keeping more serotonin in the synaptic gap between neurons. They achieve this through preventing enzymatic degradation of synaptic serotonin. SSRIs do not enhance serotonin production. Risch and Nemeroff state; “…depressed patients were treated with low-tryptophan diets that were supplemented with high doses of neutral amino acids [which compete with tryptophan for transport through the blood-brain barrier]… Remitted depressed subjects receiving serotonergic antidepressants (e.g. fluoxetine [Prozac®], fluvoxamine) who were challenged with low-tryptophan diet supplemented with neutral amino acids promptly relapsed into severe clinical depression. When the tryptophan supplementation was provided, the patients promptly recovered…”

The many successful published studies using 5-HTP show that 5-HTP, by naturally elevating brain serotonin, can alleviate the serotonin-deficiency syndrome without any help from SSRI drugs. Yet the study related by Risch and Nemeroff eloquently shows that the success of SSRI drugs is crucially dependent upon the brain producing adequate serotonin, (from either tryptophan or 5-HTP) and that brain serotonin production is the controlling or rate-limiting variable underlying the apparent success of SSRIs.

It appears that the more logical and economically sound choice to alleviate conditions that result from the serotonin deficiency syndrome is 5-HTP, the immediate precursor of the deficient substance.



Van Praag’s and Young’s work suggests that 5-HTP is more likely to be effective for those suffering an anxious, agitated, aggressive, irritable depression and is rarely effective for those suffering from a severe, vegetative, total “blahs” type depression.

5-HTP may also be helpful in some cases of compulsive carbohydrate overeating, alcohol addiction and compulsive gambling (specific forms of OCD), as well as for insomnia.

Side effects of 5-HTP are occasional gastrointestinal upset, hypomania and euphoria, but whilst 5-HTP is a natural substance normally made by the brain, without medical supervision prudence suggests limiting daily dosage to 100 mg to 200 mg; the dose shown to be effective in human clinical studies.

Research also shows that both tryptophan and even more so 5-HTP, increase the activity of MAO inhibitor drugs, tricyclic antidepressants and selective serotonin inhibitor (SSRI) drugs, such as Prozac®, Paxil® and Zoloft®. Therefore L-tryptophan and especially 5-HTP should only be used by anyone taking any of these drugs ONLY under their prescribing physician’s consent and supervision.



  1. Zmilacher, et al. L-5-Hydroxytryptophan Alone and in Combination with a Peripheral Decarboxylase Inhibitor in the Treatment of Depression. Neuropsychobiology. 1988; 20: 28-35.
  2. Byerley, et al. 5-Hydroxytryptophan: A Review of Its Antidepressant Efficacy and Adverse Effects. J Clin Psychopharmacol 1987; 7: 127-37.
  3. Risch and C. Nemeroff. Neurochemical Alterations of Serotonergic Neuronal Systems in Depression. J Clin Psychiatry. 1992; 53: 3-7.
  4. Poeldinger, et al. A Functional-Dimensional Approach to Depression: Serotonin Deficiency as a Target Syndrome in a Comparison of 5 -Hydroxytryptophan and Fluvoxamine. Psychopathology. 1991; 24: 53-81.
  5. van Praag. Management of Depression with Serotonin Precursors. Biol Psychiatry. 1981; 16: 291-310.
  6. S Takahashi, et al. Effect of L-5-Hydroxytryptophan on Brain Monoamine Metabolism and Evaluation of Its Clinical Effect in Depressed Patients. Psychiat Res 1975; 12: 177-87.
  7. Kahn and H. Westenberg. L-5-Hydroxytryptophan in the Treatment of Anxiety Disorders. J Affect Disord, 1985; 8: 197-200.
  8. Linnoila and M. Virkkunen. Aggression, Suicidality, and Serotonin. J Clin Psychiatry. 1992; 53: 46-51.
  9. Buydens-Branchey, et al. Age of Alcoholism Onset. II. Relationship to Susceptibility to Serotonin Precursor Availability. Arch Gen Psychiatry. 1989; 46: 231-36.
  10. Wurtman. Carbohydrate Craving, Mood Changes and Obesity. J Clin Psychiatry. 1988; 49: 37-39.
  11. Cangiano, et al. Eating Behavior and Adherence to Dietary Prescriptions in Obese Adult Subjects Treated with 5-Hydroxytryptophan. Am J Clin Nutr 1992; 56: 863-7.
  12. Murphy et al. Obsessive-Compulsive Disorder as a 5-HT Sub-sytem -Related Behavioural Disorder. Bri J Psychiatry. 1989; 155: 15-24.
  13. Maurizi. The Therapeutic Potential for Tryptophan and Melatonin: Possible Roles in Depression, Sleep, Alzheimer’s Disease and Abnormal Aging. Med Hypoth. 1990; 31: 233-42.
  14. DeBenedittis and R. Massei. 5-HT Precursors in Migraine Prophy laxis: A Double-Blind Cross-Over Study with L-5-Hydroxytryptophan versus Placebo. Clin J Pain. 1986; 3: 123-29.
  15. Robertson and T. Monte. Natural Prozac Learning to Release Your Body’s Own Anti-Depressants. San Francisco: Harper; 1997.
  16. B6The Natural Healer. New Canaan: Keats: 1984.
  17. van Praag. Studies of the Mechanism of Action of Serotonin Precursors in Depression. Psychopharmacol Bull. 1984; 20: 599-602.
  18. Hartvig et al. Pyridoxine Effect on Synthesis Rate of Serotonin in the Monkey Brain Measured with Positron Emission Tomography. J Neural Trans. 1995; 102: 91-7.
  19. Dakshinamurti, et al. Influence of B Vitamins on Binding Properties of Serotonin Receptors in CNS of Rats. Klin Wochenschr. 1990; 68: 142-45.
  20. Jacobsen, et al. Cardiac Manifestations in Mid-gut Carcinoid Disease. Eur Heart J. 1995; 16: 263-68.
  21. Hoshino, et al. Serum Serotonin Levels of Normal Subjects in Physiological State and Stress Conditions. Jpn J Psychosom Med. 1979; 19: 283-93.
  22. van Praag. Central Monoamine Metabolism in Depressions. I. Serotonin and Related Compounds. Compreh Psychiatry. 1980; 21: 30-43.
  23. Li Kam Wa, et al. Blood and Urine 5-Hydroxytryptamine [Serotonin] Levels after Administration of Two 5-Hydroxytryptophan Precursors in Normal Man. Bri J Clin Pharmacol. 1995; 39:327-29.
  24. Huether, et al. The Metabolic Fate of Infused L-Tryptophan in Men: Possible Clinical Implications of the Accumulation of Circulating Tryptophan and Tryptophan Metabolites. Psychopharmacol (Germany). 1992; 109: 442-32.
  25. Tornebrandt, et al. Heart Involvement in Metastatic Carcinoid Disease. Clin Cardiol. 1986; 9 (1).
  26. Arora and R. Warner. Do Indole Markers Predict Carcinoid Heart Disease? Chest. 1986; 90: 87-9.
  27. Werbach. Nutritional Influences on Illness, 2nd ed. Atherosclerosis, 57-102. Tarzana, CA: Third Line Press; 1996.
  28. Turlapaty and B. Altura. Magnesium Deficiency Produces Spasms of Coronary Arteries: Relationship to Etiology of Sudden Death Ischemic Heart Disease. Science. 1980; 208: 198-200.


Lost your password?